TACTICAL COMBAT CASUALTY CARE: GUIDELINES FOR MEDICAL PERSONNEL (TCCC-MP, 2021)


In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells represents an important cell source for diabetes research.Here, we fully characterized iPSC-derived beta cell function in vitro and in vivo in humanized mice.Using a 7-stage protocol, human iPSCs were differentiated into islet-like aggregates with a yield of in

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Downregulation of Cyclophilin A by siRNA diminishes non-small cell lung cancer cell growth and metastasis via the regulation of matrix metallopeptidase 9

Abstract Background Cyclophilin A (CypA) is a cytosolic protein possessing peptidyl-prolyl isomerase activity that was recently reported to be overexpressed in several cancers.Here, we explored the biology and molecular mechanism of CypA in non-small cell lung cancer (NSCLC).Methods The expression of CypA in turbo air m3f24-1-n human NSCLC cell lin

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Mitochondrial Role in Intrinsic Apoptosis Induced by a New Synthesized Chalcone in Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the fourth cause of cancer-related deaths worldwide.Presently, a few drugs are available for HCC treatment and prevention, including both natural and synthetic compounds.In this study, a new chalcone, (E)-1-(2,4,6-triethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (E

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Chemotherapeutic Strategies with Valnemulin, Tilmicosin, and Tulathromycin to Control Mycoplasma hyopneumoniae Infection in Pigs

Mycoplasma hyopneumoniae is the primary agent of Swine Enzootic Pneumonia (SEP).Vaccines reduce the clinical manifestation of the disease but do not prevent infection.The present study aimed to evaluate the use of antimicrobial drugs to minimize the impact of M.hyopneumoniae.For this, 32 pregnant female pigs and their litters were selected and then

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